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新光触发技术实现细胞钙离子动态调控及动物行为操控
研究背景钙（Ca2+）信号在调节细胞生理过程中起着重要作用，但迄今为止，对于细胞在外界刺激下产生过氧化氢（H2O2）并通过此激发内部钙离子动态的探索并不多见。本研究利用基于光催化剂的金属-有机框架（DCSA-MOFs）实现了对细胞、多细胞球体和器官中钙离子响应的调控。通过高效的光催化氧还原反应，DCSA-MOFs可以快速触发内质网中钙离子的释放，从而实现对细胞内钙离子动态的精确调控，进而在二维和三
2024/05/17 admin
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Toxicology: 葡醛内酯降低对二甲苯中枢神经毒性的新作用
2019年12月，Shen’s lab在Toxicology在线发表了题为“D-Glucuronolactone attenuates para-xylene-induced defects in neuronal development and plasticity in Xenopus tectum in vivo”研究论文，阐述了葡醛内酯可以降低对二甲苯对中枢神经系统毒性的新作用。对二甲苯（
2020/11/28
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Nature Communications：兴奋抑制平衡对神经环路结构和功能可塑性影响的新发现
神经元是神经系统的基本结构和机能单位。大脑由上百亿个神经元组成，堪称人类最复杂的器官。大脑皮质（即大脑表层）主要由两类神经细胞构成，一类是兴奋性神经细胞，一类是抑制性神经细胞。大脑内的兴奋性神经递质主要是谷氨酸，而抑制性神经递质主要是γ-氨基丁酸。兴奋性和抑制性的动态平衡（E/I balance）是大脑正常功能和可塑性形成和维持的重要基础，如果这个平衡被打破则会诱发癫痫、帕金森、抑郁症等多种神经疾
2018/07/25
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视觉经验依赖的神经元结构和功能可塑性调控的HDAC1依赖机制
The Internet continues to grow and develop, has become the preferred way to businesses and individuals seeking business opportunities
2018/07/08 admin
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![Experience-Dependent Bimodal Plasticity of Inhibitory Neurons in Early Development]()
Experience-Dependent Bimodal Plasticity of Inhibitory Neurons in Early Development
He, H. Y., W. Shen, M. Hiramoto and H. T. Cline (2016). "Experience-Dependent Bimodal Plasticity of Inhibitory Neurons in Early Development." Neuron 90(6): 1203-1214.Inhibitory neurons are h
2020/12/14 admin
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![对二甲苯对非洲爪蟾神经细胞凋亡和行为学影响的机制研究进展]()
对二甲苯对非洲爪蟾神经细胞凋亡和行为学影响的机制研究进展
The Internet continues to grow and develop, has become the preferred way to businesses and individuals seeking business opportunities
2020/12/14 admin
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![HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the Developing Xenopus Tectum]()
HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the Developing Xenopus Tectum
Gao, J., H. Ruan, X. Qi, Y. Tao, X. Guo and W. Shen (2016). "HDAC3 But not HDAC2 Mediates Visual Experience-Dependent Radial Glia Proliferation in the Developing Xenopus Tectum." Front Cell
2020/12/14 admin
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![Increased apoptosis and abnormal visual behavior by histone modifications with exposure to para-xylene in developing Xenopus]()
Increased apoptosis and abnormal visual behavior by histone modifications with exposure to para-xylene in developing Xenopus
Gao, J., H. Ruan, X. Qi, X. Guo, J. Zheng, C. Liu, Y. Fang, M. Huang, M. Xu and W. Shen (2016). "Increased apoptosis and abnormal visual behavior by histone modifications with exposure to para-xy
2020/12/14 admin
