Annual Review of Biochemistry

The *Annual Review of Biochemistry* (ANNU REV BIOCHEM, ISSN: 0066-4154) stands as a preeminent and authoritative journal in the life sciences, consistently ranked among the most impactful publications in its field. With an impressive 2026 Impact Factor of 24.900 and a JCR Quartile ranking of Q1, the journal holds a top-tier position, serving as an essential resource for the global biochemical community. Its scope encompasses the full breadth of biochemistry and molecular biology, publishing critical and comprehensive review articles that synthesize the most significant recent advances. Main topics covered include macromolecular structure and function, enzymology, signal transduction, metabolism, gene regulation, proteomics, and the mechanistic underpinnings of cellular processes. Unlike journals that publish primary research, the *Annual Review of Biochemistry* exclusively features invited, authoritative review articles written by leading experts. These reviews are designed to provide a critical, evaluative synthesis of the current literature, highlighting key discoveries, unresolved questions, and future directions. The target audience includes academic researchers, principal investigators, graduate students, and industry scientists who require a deep, integrated understanding of rapidly evolving topics. Published by Annual Reviews, a nonprofit scientific publisher, the journal is dedicated to advancing knowledge through rigorous synthesis. While not fully open access by default, it offers options for open access publication and provides significant institutional access. Its exceptional Impact Factor and consistent Q1 ranking solidify its standing as an indispensable, gold-standard reference in biochemistry, setting the benchmark for comprehensive and insightful scientific review.