Journal of Biological Chemistry

The Journal of Biological Chemistry (J Biol Chem, ISSN: 0021-9258) is a peer-reviewed academic journal that has long served as a cornerstone publication in the field of biochemistry and molecular biology. Its scope encompasses the full spectrum of biological chemistry, with a particular emphasis on the molecular mechanisms underlying cellular processes. Main topics covered include signal transduction, metabolism, gene regulation, protein structure and function, enzymology, and membrane biology. The journal primarily publishes original research articles, which are rigorously peer-reviewed to ensure high standards of experimental design and mechanistic insight. While review articles are not a central focus, the journal occasionally features thematic reviews and perspectives. The target audience comprises academic researchers, postdoctoral fellows, and graduate students working in biochemistry, cell biology, and related biomedical disciplines. A notable feature of the Journal of Biological Chemistry is its commitment to open access; it is a fully open access journal published by the American Society for Biochemistry and Molecular Biology (ASBMB), ensuring that all content is freely available to the global scientific community. With an Impact Factor of 4.000 as of 2026, the journal is positioned in the Q2 quartile within the category of Biochemistry & Molecular Biology. In China’s CAS journal classification, it is rated as a 2区 (Zone 2) journal in biology, reflecting its solid standing as a respected, mid-tier venue that consistently publishes sound, reproducible, and mechanistically meaningful research. Despite competitive impact metrics in a crowded field, JBC remains a highly regarded and widely cited journal for fundamental biochemical discovery.